Atherogenic Index of Plasma, Castelli Risk Index and Atherogenic Coefficient- New Parameters in Assessing Cardiovascular Risk

Coronary artery disease is the epidemic of modern civilization in which dyslipidemia contributes significantly to its pathogenesis. We studied the significance of three important lipid ratios i.e. Atherogenic Index of Plasma (AIP) {(logTG)/HDLc}, Castelli’s Risk Index I & II (TC/HDLc and LDLc/HDLc respectively) and Atherogenic coefficient (AC) {(Non-HDLc)/HDLc} in predicting the risk of CAD. A case-control study was conducted with 60 angiographically confirmed patients and 60 healthy volunteers. Lipid profile {Total cholesterol (TC), Triacylglycerol (TG), HDLc, LDLc} was measured on automated analyser and ratios were calculated for both case and control groups. Statistical analysis was done using SPSS software. TC and LDLc were not different between the two groups. But the ratios based on these parameters were significantly different (p<0.05). These ratios can contribute significantly to the estimation of risk of CAD especially when absolute values of lipid profile parameters are not markedly deranged or in centres with insufficient resources.